USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P49721 USC-OGP 2-DE database:  P49721 P49721 General information about the entry View entry in simple text format Entry name PSB2_HUMAN Primary accession number P49721 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Proteasome subunit beta type-2; EC=3.4.25.1 {ECO:0000269|PubMed:27176742}; AltName: Full=Macropain subunit C7-I; AltName: Full=Multicatalytic endopeptidase complex subunit C7-I; AltName: Full=Proteasome component C7-I;. Gene name Name=PSMB2 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0550: pI=6.52; Mw=22881 PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-1029: pI=6.55; Mw=22866 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1302: pI=6.88; Mw=22783 Cross-references UniProtKB/Swiss-Prot P49721; PSB2_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PSB2_HUMAN Primary accession number P49721 Secondary accession number(s) D3DPS0 P31145 Q9BWZ9 Sequence was last modified on  October 1, 1996 (version 1) Annotations were last modified on  March 15, 2017 (version 179) Name and origin of the protein Description RecName: Full=Proteasome subunit beta type-2; EC=3.4.25.1 {ECO:0000269|PubMed:27176742}; AltName: Full=Macropain subunit C7-I; AltName: Full=Multicatalytic endopeptidase complex subunit C7-I; AltName: Full=Proteasome component C7-I; Gene name Name=PSMB2 Encoded on Name=PSMB2 Keywords 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Host-virus interaction; Hydrolase; Nucleus; Protease; Proteasome; Reference proteome; Threonine protease. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL D26599; BAA05646.1; -; mRNA EMBL CR456862; CAG33143.1; -; mRNA EMBL BT007137; AAP35801.1; -; mRNA EMBL AL354864; CAC36031.2; -; Genomic_DNA EMBL AL157951; CAC36031.2; JOINED; Genomic_DNA EMBL AL357035; CAC36031.2; JOINED; Genomic_DNA EMBL AL357035; CAI22074.1; -; Genomic_DNA EMBL AL354864; CAI22074.1; JOINED; Genomic_DNA EMBL AL157951; CAI22074.1; JOINED; Genomic_DNA EMBL AL157951; CAI23521.1; -; Genomic_DNA EMBL AL354864; CAI23521.1; JOINED; Genomic_DNA EMBL AL357035; CAI23521.1; JOINED; Genomic_DNA EMBL CH471059; EAX07406.1; -; Genomic_DNA EMBL CH471059; EAX07407.1; -; Genomic_DNA EMBL BC101836; AAI01837.1; -; mRNA EMBL BC105126; AAI05127.1; -; mRNA EMBL BC107901; AAI07902.1; -; mRNA CCDS CCDS394.1; -; . PIR S55040; S55040; . RefSeq NP_002785.1; NM_002794.4; . UniGene Hs.471441; -; . PDB 4R3O; X-ray; 2.60 A; K/Y=1-199 PDB 4R67; X-ray; 2.89 A; 0/K/Y/m=1-199 PDB 5A0Q; EM; 3.50 A; K/Y=1-201 PDB 5GJQ; EM; 4.50 A; d/r=1-201 PDB 5GJR; EM; 3.50 A; d/r=1-201 PDB 5L4G; EM; 4.02 A; 2/V=1-201 PDB 5LE5; X-ray; 1.80 A; J/X=1-201 PDB 5LEX; X-ray; 2.20 A; J/X=1-201 PDB 5LEY; X-ray; 1.90 A; J/X=1-201 PDB 5LEZ; X-ray; 2.19 A; J/X=1-201 PDB 5LF0; X-ray; 2.41 A; J/X=1-201 PDB 5LF1; X-ray; 2.00 A; J/X=1-201 PDB 5LF3; X-ray; 2.10 A; J/X=1-201 PDB 5LF4; X-ray; 1.99 A; J/X=1-201 PDB 5LF6; X-ray; 2.07 A; J/X=1-201 PDB 5LF7; X-ray; 2.00 A; J/X=1-201 PDB 5T0C; EM; 3.80 A; AQ/BQ=1-201 PDB 5T0G; EM; 4.40 A; Q=1-201 PDB 5T0H; EM; 6.80 A; Q=1-201 PDB 5T0I; EM; 8.00 A; Q=1-201 PDB 5T0J; EM; 8.00 A; Q=1-201 PDBsum 4R3O; -; . PDBsum 4R67; -; . PDBsum 5A0Q; -; . PDBsum 5GJQ; -; . PDBsum 5GJR; -; . PDBsum 5L4G; -; . PDBsum 5LE5; -; . PDBsum 5LEX; -; . PDBsum 5LEY; -; . PDBsum 5LEZ; -; . PDBsum 5LF0; -; . PDBsum 5LF1; -; . PDBsum 5LF3; -; . PDBsum 5LF4; -; . PDBsum 5LF6; -; . PDBsum 5LF7; -; . PDBsum 5T0C; -; . PDBsum 5T0G; -; . PDBsum 5T0H; -; . PDBsum 5T0I; -; . PDBsum 5T0J; -; . ProteinModelPortal P49721; -; . SMR P49721; -; . BioGrid 111663; 97; . DIP DIP-33848N; -; . IntAct P49721; 36; . MINT MINT-1144735; -; . STRING 9606.ENSP00000362334; -; . BindingDB P49721; -; . ChEMBL CHEMBL3492; -; . DrugBank DB08889; Carfilzomib; . MEROPS T01.984; -; . iPTMnet P49721; -; . PhosphoSitePlus P49721; -; . SwissPalm P49721; -; . BioMuta PSMB2; -; . DMDM 1709762; -; . OGP P49721; -; . REPRODUCTION-2DPAGE IPI00028006; -; . REPRODUCTION-2DPAGE P49721; -; . EPD P49721; -; . MaxQB P49721; -; . PaxDb P49721; -; . PeptideAtlas P49721; -; . PRIDE P49721; -; . TopDownProteomics P49721; -; . DNASU 5690; -; . Ensembl ENST00000373237; ENSP00000362334; ENSG00000126067; . GeneID 5690; -; . KEGG hsa:5690; -; . UCSC uc001bzf.4; human; . CTD 5690; -; . DisGeNET 5690; -; . GeneCards PSMB2; -; . HGNC HGNC:9539; PSMB2; . HPA HPA026322; -; . HPA HPA026324; -; . MIM 602175; gene; . neXtProt NX_P49721; -; . OpenTargets ENSG00000126067; -; . PharmGKB PA33884; -; . eggNOG KOG0177; Eukaryota; . eggNOG COG0638; LUCA; . GeneTree ENSGT00640000091536; -; . HOGENOM HOG000188743; -; . HOVERGEN HBG000815; -; . InParanoid P49721; -; . KO K02734; -; . OMA DRYHDPE; -; . OrthoDB EOG091G0K9M; -; . PhylomeDB P49721; -; . TreeFam TF106219; -; . Reactome R-HSA-1169091; Activation of NF-kappaB in B cells; . Reactome R-HSA-1234176; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; . Reactome R-HSA-1236974; ER-Phagosome pathway; . Reactome R-HSA-1236978; Cross-presentation of soluble exogenous antigens (endosomes); . Reactome R-HSA-174084; Autodegradation of Cdh1 by Cdh1:APC/C; . Reactome R-HSA-174113; SCF-beta-TrCP mediated degradation of Emi1; . Reactome R-HSA-174154; APC/C:Cdc20 mediated degradation of Securin; . Reactome R-HSA-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; . Reactome R-HSA-174184; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; . Reactome R-HSA-180534; Vpu mediated degradation of CD4; . Reactome R-HSA-180585; Vif-mediated degradation of APOBEC3G; . Reactome R-HSA-187577; SCF(Skp2)-mediated degradation of p27/p21; . Reactome R-HSA-195253; Degradation of beta-catenin by the destruction complex; . Reactome R-HSA-202424; Downstream TCR signaling; . Reactome R-HSA-211733; Regulation of activated PAK-2p34 by proteasome mediated degradation; . Reactome R-HSA-2467813; Separation of Sister Chromatids; . Reactome R-HSA-2871837; FCERI mediated NF-kB activation; . Reactome R-HSA-349425; Autodegradation of the E3 ubiquitin ligase COP1; . Reactome R-HSA-350562; Regulation of ornithine decarboxylase (ODC); . Reactome R-HSA-382556; ABC-family proteins mediated transport; . Reactome R-HSA-450408; AUF1 (hnRNP D0) binds and destabilizes mRNA; . Reactome R-HSA-4608870; Asymmetric localization of PCP proteins; . Reactome R-HSA-4641257; Degradation of AXIN; . Reactome R-HSA-4641258; Degradation of DVL; . Reactome R-HSA-5358346; Hedgehog ligand biogenesis; . Reactome R-HSA-5362768; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; . Reactome R-HSA-5607761; Dectin-1 mediated noncanonical NF-kB signaling; . Reactome R-HSA-5607764; CLEC7A (Dectin-1) signaling; . Reactome R-HSA-5610780; Degradation of GLI1 by the proteasome; . Reactome R-HSA-5610783; Degradation of GLI2 by the proteasome; . Reactome R-HSA-5610785; GLI3 is processed to GLI3R by the proteasome; . Reactome R-HSA-5632684; Hedgehog 'on' state; . Reactome R-HSA-5658442; Regulation of RAS by GAPs; . Reactome R-HSA-5668541; TNFR2 non-canonical NF-kB pathway; . Reactome R-HSA-5676590; NIK-->noncanonical NF-kB signaling; . Reactome R-HSA-5678895; Defective CFTR causes cystic fibrosis; . Reactome R-HSA-5687128; MAPK6/MAPK4 signaling; . Reactome R-HSA-5689603; UCH proteinases; . Reactome R-HSA-5689880; Ub-specific processing proteases; . Reactome R-HSA-68827; CDT1 association with the CDC6:ORC:origin complex; . Reactome R-HSA-68949; Orc1 removal from chromatin; . Reactome R-HSA-69017; CDK-mediated phosphorylation and removal of Cdc6; . Reactome R-HSA-69229; Ubiquitin-dependent degradation of Cyclin D1; . Reactome R-HSA-69481; G2/M Checkpoints; . Reactome R-HSA-69601; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; . Reactome R-HSA-8852276; The role of GTSE1 in G2/M progression after G2 checkpoint; . Reactome R-HSA-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; . Reactome R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation; . ChiTaRS PSMB2; human; . GeneWiki PSMB2; -; . GenomeRNAi 5690; -; . PRO PR:P49721; -; . Proteomes UP000005640; Chromosome 1; . Bgee ENSG00000126067; -; . CleanEx HS_PSMB2; -; . ExpressionAtlas P49721; baseline and differential; . Genevisible P49721; HS; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0005654; C:nucleoplasm; IDA:HPA; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0000502; C:proteasome complex; IDA:UniProtKB; . GO GO:0005839; C:proteasome core complex; ISS:UniProtKB; . GO GO:0004298; F:threonine-type endopeptidase activity; IEA:UniProtKB-KW; . GO GO:0031145; P:anaphase-promoting complex-dependent catabolic process; TAS:Reactome; . GO GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; TAP-dependent; TAS:Reactome GO GO:0038095; P:Fc-epsilon receptor signaling pathway; TAS:Reactome; . GO GO:0000165; P:MAPK cascade; TAS:Reactome; . GO GO:0090090; P:negative regulation of canonical Wnt signaling pathway; TAS:Reactome; . GO GO:0010972; P:negative regulation of G2/M transition of mitotic cell cycle; TAS:Reactome; . GO GO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome; . GO GO:0038061; P:NIK/NF-kappaB signaling; TAS:Reactome; . GO GO:0090263; P:positive regulation of canonical Wnt signaling pathway; TAS:Reactome; . GO GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition; TAS:Reactome; . GO GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; TAS:Reactome; . GO GO:0016579; P:protein deubiquitination; TAS:Reactome; . GO GO:0000209; P:protein polyubiquitination; TAS:Reactome; . GO GO:0006521; P:regulation of cellular amino acid metabolic process; TAS:Reactome; . GO GO:0043488; P:regulation of mRNA stability; TAS:Reactome; . GO GO:0061418; P:regulation of transcription from RNA polymerase II promoter in response to hypoxia; TAS:Reactome; . GO GO:0014070; P:response to organic cyclic compound; IEA:Ensembl; . GO GO:0010243; P:response to organonitrogen compound; IEA:Ensembl; . GO GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome; . GO GO:0002223; P:stimulatory C-type lectin receptor signaling pathway; TAS:Reactome; . GO GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome; . GO GO:0055085; P:transmembrane transport; TAS:Reactome; . GO GO:0033209; P:tumor necrosis factor-mediated signaling pathway; TAS:Reactome; . GO GO:0016032; P:viral process; IEA:UniProtKB-KW; . GO GO:0060071; P:Wnt signaling pathway; planar cell polarity pathway; TAS:Reactome Gene3D 3.60.20.10; -; 1; . InterPro IPR029055; Ntn_hydrolases_N; . InterPro IPR016050; Proteasome_bsu_CS; . InterPro IPR001353; Proteasome_sua/b; . InterPro IPR023333; Proteasome_suB-type; . Pfam PF00227; Proteasome; 1; . SUPFAM SSF56235; SSF56235; 1; . PROSITE PS00854; PROTEASOME_BETA_1; 1; . PROSITE PS51476; PROTEASOME_BETA_2; 1; .

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